Production of indole by wine-associated microorganisms under oenological conditions

A high concentration of indole has been linked to ‘plastic-like’ off-flavour in wines, predominantly in wines produced under sluggish fermentation conditions. The purpose of this study was to determine the ability of yeast and bacteria to form indole and whether tryptophan was required for indole accumulation during winemaking. Wine-associated yeast and bacteria species (Saccharomyces cerevisiae, Saccharomyces bayanus, Candida stellata, Hanseniaspora uvarum, Kluyveromyces thermoloterans, Oenococcus oeni, Lactobacillus lindneri, Pediococcus cerevisiae and Pediococcus parvulus) were screened for their potential to generate indole during alcoholic or malolactic fermentation. Tryptophan was required for the accumulation of indole in chemically defined medium, and all yeast and bacteria fermentations were able to accumulate indole. C. stellata showed the greatest potential for indole formation (1033 μg/L) and among the bacteria, the highest concentration was generated by L. lindneri (370 μg/L). Whether primary fermentation is the principle cause of indole formation remains to be determined. We hypothesise that during an efficient fermentation, indole is removed through catabolic metabolism, but, when a sluggish fermentation arises, non-Saccharomyces species might produce excess indole that is still present by end of fermentation.     

Preface: Special Issue on Nasa Formal Methods Symposium 2009

This journal issue contains seven articles representing extended versions of the best papers selected from the proceedings of the First NASA Formal Methods Symposium (NFM 2009). The NASA Formal Methods Symposium is a new annual event that focuses on formal techniques, their theory, current capabilities, and limitations, as well as their application to aerospace, robotics, and other safety-critical systems.     

Characterisation of the supramolecular structure of chemically and physically modified regenerated cellulosic fibres by means of high-resolution Carbon-13 solid-state NMR

Carbon-13 high-resolution solid-state NMR techniques have been invaluable in elucidating the structure of regenerated cellulosic materials. Studies of a range of fibres have shown systematic changes in chemical shifts, which can be related to the influences of physical processing or chemical modification. A constrained curve fitting method has been applied, where the C4 spectral envelope is represented as the sum of contributions from polymer in ordered, partially-ordered and disordered environments, associated with differing conformational arrangements of the cellulose hydroxymethyl and glycocidic bonds. The empirical gamma-gauche effect seems likely to provide the best rationalization for the relationship between C4 shifts and conformational order, taking into account the increased range of bond angles in disordered environments. The quantification of proportions of polymer units within different conformational groupings will provide new insights into the development of supramolecular texture. This will allow better appreciation of the relationships between fibre processing and ultimate fibre performance.     

Synthetic routes to lipidic diamines and amino alcohols: A class of potential antiinflammatory agents

Simple and efficient methods for the synthesis of lipidic amino alcohols and diamines are described in this paper. Lipidic 2-amino alcohols and 1,3-diamines can be synthesized starting from synthetic lipidic α-amino acids. Alternatively, commercially available lipidic 1,2-diols may be used as starting material for the synthesis of 2-amino alcohols. Initial experiments on the in vivo antiinflammatory activity of the compounds synthesized gave promising results.     

ISE-optimal nonminimum-phase compensation for nonlinear processes

This work concerns the optimal regulation of single-input–single-output nonminimum-phase nonlinear processes. The problem of calculation of an ISE-optimal, statically equivalent, minimum-phase output for nonminimum-phase compensation is formulated using Hamilton–Jacobi theory and the normal form representation of the nonlinear system. A Newton–Kantorovich iteration is developed for the solution of the pertinent Hamilton–Jacobi equations, which involves solving a Zubov equation at each step of the iteration. The method is applied to the problem of controlling a nonisothermal CSTR with Van de Vusse kinetics, which exhibits nonminimum-phase behaviour.     

Flow Routing and its Performance Analysis in Optical IP Networks

Optical packet-switching networks deploying buffering, wavelength conversion and multi-path routing have been extensively studied in recent years to provide high capacity transport for Internet traffic. However due to packet-based routing and switching, such a network could result in significant disorder and delay variation of packets when they are received by end users, thus increasing the burstiness of the Internet traffic and causing higher-layer protocol to malfunction. This paper addresses a novel routing and switching method for optical IP networks — flow routing, and its facilitating protocol. Flow routing deals with packet-flows to reduce flow corruption due to packet out-of-order, delay variation and packet loss, without using complicate control mechanism. Detailed performance analysis is given for output-buffered optical routers adopting flow routing. Two flow-oriented discarding techniques, i.e., flow discard (FD) and early flow discard (EFD), are discussed. Compared with optical packet-switching routers, a remarkable improvement of good-throughput is obtained in the optical flow-routers, especially under high congestion periods. We conclude that EFD behaves as a robust technique, which is more tolerant than FD to the change of traffic and transmission system factors.     

Phosphorus: 光子网格的分布式控制平面技术

G2MPLS is a Network Control Plane (NCP) architecture that implements the concept of Grid Network Services (GNS) required for implementing photonic Grids. It provides part of the functionalities related to the selection, co allocation and maintenance of both Grid and network resources through a set of seamless procedures at the user to network and inter domain boundaries. G2MPLS main features and procedures are presented in this document, as well as the considerations to deploy it and facilitate its dissemination.     

Social value creation through digital activism in an online health community

The study explores how online health communities produce social value by uniting individuals under a common purpose, to advance healthcare in post‐conflict states. We selected MedicineAfrica – a digital platform known for creating social value by providing medical education in regions with under‐resourced healthcare systems – and drew on multiple data collection methods. We found that it is through a unique form of digital health activism that social value is created in this context. Drawing on a sociological understanding of digital health activism, we make the following contributions: First, we identify three types of non‐economic, social value: cognitive, professional and epistemic. Second, we indicate that social value creation is enabled by three emergent forms of digital health activism (ie, philanthropic, moral and reciprocal activity). Third, we elicit three enabling mechanisms explaining how these forms of activism are technically and socially afforded through the platform's connective capacity and emerging collective practices in tandem with its members' growing commitment. Our article contributes to the growing IS literature on digital activism by offering a framework that elucidates how digital health activism relates to social value creation. The article provides practical implications as to how platforms can enable sustainable online (health) communities.